Document Detail

Cefotaxime therapy of neonatal gram-negative bacillary meningitis.
MedLine Citation:
PMID:  3900946     Owner:  NLM     Status:  MEDLINE    
Seven neonates were treated with cefotaxime during eight episodes of Gram-negative bacillary meningitis and sepsis. The causative organisms were Escherichia coli in six cases and Klebsiella pneumoniae and Enterobacter sakazakii in one each. After identification of the pathogen cefotaxime was used alone in six instances. Two patients with brain abscesses received adjunctive therapy with another antibiotic. The sterility of cerebrospinal fluid was documented after a mean of 3.3 days of therapy. Mean cerebrospinal fluid bactericidal titer was 1:64. All patients recovered with good neurologic outcome. Cefotaxime in a dosage of 150 mg/kg/day divided every 6 hours intravenously seems safe and effective therapy for neonatal Gram-negative bacillary meningitis.
S H Naqvi; M A Maxwell; L M Dunkle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric infectious disease     Volume:  4     ISSN:  0277-9730     ISO Abbreviation:  Pediatr Infect Dis     Publication Date:    1985 Sep-Oct
Date Detail:
Created Date:  1985-11-18     Completed Date:  1985-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8209468     Medline TA:  Pediatr Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
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MeSH Terms
Cefotaxime / administration & dosage,  therapeutic use*
Enterobacter / isolation & purification
Enterobacteriaceae Infections / drug therapy
Escherichia coli / isolation & purification
Escherichia coli Infections / drug therapy
Infant, Newborn
Injections, Intravenous
Klebsiella Infections / drug therapy
Klebsiella pneumoniae / isolation & purification
Meningitis / drug therapy*,  microbiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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