Document Detail

Cefotaxime-eluting covered self-expandable stents in a canine biliary model: scanning electron microscopic study of biofilm formation.
MedLine Citation:
PMID:  23034797     Owner:  NLM     Status:  Publisher    
BackgroundAs bacterial attachment and subsequent biofilm formation on the surface of a stent lumen may be important in initiating sludge formation and subsequent stent blockage, there is a need for antibiotic-eluting stents to prevent sludge formation by bacterial attachment and colonization.PurposeTo evaluate the antimicrobial effects of cefotaxime-eluting covered self-expandable stents (CE-CSEMS) in a canine biliary model by using scanning electron microscopy (SEM) to analyze biofilm formation on the inner surface of the stents.Material and MethodsThree 10% (wt/vol) CE-CSEMS, three 20% (wt/vol) CE-CSEMS, and three control stents (CS) were endoscopically inserted into the bile ducts of nine mongrel dogs, which were followed up for 8 weeks. Gross and SEM examinations were performed to access the development and degree of biofilm formation in dogs with CS and CE-CSEMS.ResultsAll stents were successfully inserted into canine bile ducts without any procedure-related complications. All nine dogs remained in good health without jaundice over the next 8 weeks. The degree of biofilm was similar in dogs implanted with CS and CE-CSEMS using two concentrations of cefotaxime either by gross inspection or SEM. All stent types showed a similar biofilm structure with relatively uniform thickness on SEM.ConclusionCefotaxime does not prevent biofilm development in a canine biliary model. Biofilm formation on the inner surface of biliary stents may be prevented by using broad-spectrum antimicrobial agents and stents that maintain a steady release of these agents for a long time, thus prolonging stent patency.
Dong Il Gwon; Sang Soo Lee; Eun-Young Kim
Related Documents :
23023947 - 1-aryl-4-silylmethyl[60]fullerenes: synthesis, properties, and photovoltaic performance.
23531157 - Electrochemically exfoliated graphene as solution-processable, highly-conductive electr...
22718327 - Computational study of au_4 cluster on a carbon nanotube with and without defects using...
23044517 - The magnetic and quantum transport properties of benzene-vanadium-borazine mixed sandwi...
17797307 - Transient particle acceleration associated with solar flares.
23616937 - Influence of diffusion on space-charge-limited current measurements in organic semicond...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  -     ISSN:  1600-0455     ISO Abbreviation:  Acta Radiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Radiology and Research Institute of Radiology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  64-slice coronary computed tomography angiography using low tube voltage of 80 kV in subjects with n...
Next Document:  Ift88 regulates Hedgehog signaling, Sfrp5 expression, and ?-catenin activity in post-natal growth pl...