Document Detail

Cefodizime administration in healthy subjects: studies of natural killer cells, urinary hormones and electrolytes.
MedLine Citation:
PMID:  2970951     Owner:  NLM     Status:  MEDLINE    
Two studies are here discussed: the first one on changes of the natural killer cell activity of PBM cells exposed in vitro to CDZ and the second one on urinary electrolytes, cortisol, aldosterone and DHEA-S circadian rhythms, evaluated in healthy subjects who received a single dose (2 g i.v.) of cefodizime (CDZ). The effect of CDZ in health includes a reduction of the circadian amplitude of natural killer cell activity. With the methods used, no difference was found between placebo and CDZ, as far as circadian rhythms of urinary electrolytes, cortisol, aldosterone and DHEA-S are concerned.
M M Ventura; M Romagnoli; S Santucci; C Sforza; G Gatti; O Carandente
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chronobiologia     Volume:  15     ISSN:  0390-0037     ISO Abbreviation:  Chronobiologia     Publication Date:    1988 Jan-Jun
Date Detail:
Created Date:  1988-10-24     Completed Date:  1988-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0434557     Medline TA:  Chronobiologia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  43-59     Citation Subset:  IM    
Clinica Medica II-Geriatria, Facoltà di Medicina e Chirurgia, Università degli Studi di Perugia, Italy.
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MeSH Terms
Adjuvants, Immunologic*
Aldosterone / urine
Cefotaxime / analogs & derivatives*,  pharmacology
Cell Line
Circadian Rhythm / drug effects*
Cytotoxicity, Immunologic
Dehydroepiandrosterone / analogs & derivatives,  urine
Dehydroepiandrosterone Sulfate
Electrolytes / urine*
Hormones / urine*
Hydrocortisone / urine
Killer Cells, Natural / drug effects,  immunology*
Reference Values
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Electrolytes; 0/Hormones; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 53-43-0/Dehydroepiandrosterone; 63527-52-6/Cefotaxime; 651-48-9/Dehydroepiandrosterone Sulfate; 69739-16-8/cefodizime

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