| Cefmenoxime kinetics during continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 3464435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kinetics of the aminothiazolyliminomethoxy cephalosporin, cefmenoxime, were determined after a 30 min intravenous infusion of 15 mg/kg body weight in 6 adult subjects undergoing continuous ambulatory peritoneal dialysis. Concentrations of cefmenoxime in serum, urine and dialysate were determined by high-pressure liquid chromatography. The mean peak serum concentration was 92.8 +/- 11.6 micrograms/ml and the harmonic mean for the elimination half-life was 5.46 h. The volume of distribution at steady-state was 14.60 +/- 3.01 l/kg. Total body clearance of the drug was 31 +/- 7.7 ml/min with 8 +/- 5% and 5.75 +/- 2.72% of the administered dose being eliminated by renal and peritoneal clearance, respectively. Peritoneal clearance for all exchanges (n = 24) was 1.93 +/- 68 ml/min. These data suggest that peritoneal losses of this drug are minimal and doses conventionally employed in advanced renal failure can be utilized in the management of systemic infections. |
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Authors:
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D A Sica; R E Polk; T M Kerkering; P Patterson; J Baggett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 30 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-12-15 Completed Date: 1986-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 713-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cefmenoxime Cefotaxime / analogs & derivatives*, metabolism Creatinine / metabolism Female Half-Life Humans Kinetics Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine; 63527-52-6/Cefotaxime; 65085-01-0/Cefmenoxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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