Document Detail


Cefetamet in the treatment of acute sinusitis in adult patients.
MedLine Citation:
PMID:  2193836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cefetamet, an oral third-generation cephalosporin, was investigated in a prospective, randomized, open, comparative trial in 41 outpatients with acute sinusitis. The efficacy of 500 mg cefetamet given orally twice daily for 7 days to 22 patients was compared with that of 500 mg cefaclor given orally three times daily for 7 days to 19 patients. Sinus punctures were performed before antimicrobial therapy in 10 patients from each treatment group. A successful bacteriological response was obtained in all the 21 assessable patients treated with cefetamet and in the cefaclor-treated group 18 assessable patients were cured and two were improved, but one failed to respond to therapy. The tolerability of both drugs was good and no withdrawals from treatment were necessary.
Authors:
U Gauger; P Inoka; G Germano; M Kissling
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  18     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
Affiliation:
Clinical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Bacterial Infections / drug therapy
Cefaclor / therapeutic use
Ceftizoxime / analogs & derivatives*,  therapeutic use
Clinical Trials as Topic
Female
Humans
Male
Middle Aged
Sinusitis / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
53994-73-3/Cefaclor; 65052-63-3/cefetamet; 68401-81-0/Ceftizoxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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