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Cefepime-related encephalopathy in peritoneal dialysis patients.
MedLine Citation:
PMID:  21354086     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Encephalopathy or neurotoxicity can occur with cefepime use in patients with impaired or relatively normal renal function. However, few articles have examined the relationship between cefepime's adverse effects and peritoneal dialysis. Here, we report the case of an 80-year-old woman with chronic renal failure on peritoneal dialysis that developed agitation, confusion, and dystonia after cefepime administration for 2 days. The clinical and electroencephalographic abnormalities improved after discontinuation the drug. We review the role of peritoneal dialysis in the development of cefepime-induced encephalopathy. Peritoneal dialysis is a less efficient way to eliminate cefepime than hemodialysis. Short-term hemodialysis might be considered to facilitate elimination of the drug in patients who have developed neurotoxicity.
Authors:
Chun-Jen Lin; Shih-Pin Chen; Shuu-Jiun Wang; Jong-Ling Fuh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Chinese Medical Association : JCMA     Volume:  74     ISSN:  1728-7731     ISO Abbreviation:  J Chin Med Assoc     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101174817     Medline TA:  J Chin Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
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