| Cefepime Therapy and All-Cause Mortality. | |
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MedLine Citation:
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PMID: 19228108 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The findings of increased all-cause mortality associated with cefepime therapy reported in a 2007 meta-analysis by Yahav and colleagues in The Lancet Infectious Disease prompted an early communication by the Food Drug Administration (FDA). The FDA stated that it would review more safety data to further evaluate the risk of death to patients treated with cefepime. The meta-analysis' conclusion and the FDA early communication have stirred up debates in many institutions about how to properly adjust their antibiotic practice. Our review of the method of the meta-analyis (e.g., the method of data collection) raises questions about its conclusion; we call for additional review of the clinical data before any effort is made to limit or eliminate cefepime from the current practice guidelines. We make a number of recommendations on the appropriate use of cefepime therapy while awaiting further FDA advice. |
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Authors:
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Thao D Nguyen; Byron Williams; Elizabeth Trang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-2-19 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Pharmacy Services and 2Infectious Disease Services, White Memorial Medical Center, Los Angeles, and 3Pharmacotherapy and Outcomes Science, School of Pharmacy, Loma Linda University, Loma Linda, California. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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