| Cefazolin is inferior to cefotetan as single-dose prophylaxis for women undergoing elective total abdominal hysterectomy. | |
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MedLine Citation:
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PMID: 7756495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this prospective, randomized, double-blind clinical trial was to compare the efficacy of 1-g doses of intravenous cefazolin with that of 1-g doses of intravenous cefotetan in preventing major operative site infections after elective abdominal hysterectomy. A major operative site infection requiring parenteral antimicrobial therapy developed in 46 (9%) of 511 evaluable women: 30 (11.6%) of 258 women given cefazolin prophylaxis and 16 (6.3%) of 253 women given cefotetan prophylaxis (relative risk, 1.84; 95% confidence interval, 1.03 to 3.29; P < .05). Risk factors for major operative site infection were younger age, lower postoperative hemoglobin concentration, and a proliferative endometrium. Ten (3.9%) of 258 women given cefazolin prophylaxis had a postoperative pelvic abscess; two of these women required additional surgical procedures, compared with two (0.8%) of 253 women given cefotetan prophylaxis who had an abscess but did not require surgery (relative risk, 4.9; 95% confidence interval, 1.09 to 22.16; P = .04). A greater number of infections and more serious infections occurred following cefazolin prophylaxis; this treatment resulted in 234 additional hospital days for administration of parenteral antimicrobial therapy. |
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Authors:
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D L Hemsell; E R Johnson; P G Hemsell; B J Nobles; B B Little; M C Heard |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 20 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-29 Completed Date: 1995-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 677-84 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas 75235-9032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cefazolin / administration & dosage, therapeutic use* Cefotetan / administration & dosage, therapeutic use* Double-Blind Method Female Follow-Up Studies Humans Hysterectomy* Microbial Sensitivity Tests Middle Aged Prospective Studies Risk Factors Surgical Procedures, Elective Surgical Wound Infection / microbiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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25953-19-9/Cefazolin; 69712-56-7/Cefotetan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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