Document Detail


Cefazolin in the treatment of acute enteric fever.
MedLine Citation:
PMID:  791088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cefazolin was used in the treatment of nine patients with acute enteric fever proven by positive blood cultures. In seven patients the causative organism was Salmonella typhi and in two it was Salmonella paratyphi B. Minimal inhibitory and minimal bactericidal concentrations of cefazolin against the nine isolates ranged between 1.95 and 3.90 mug/ml. Cefazolin was administered either intramuscularly or intravenously in a daily dose of 3 to 6 g for 11 to 16 days. The mean peak serum antibiotic concentration after a 0.5-g intravenous injection was 64.4 mug/ml, and the mean trough concentration, 3 h later, was 12.7 mug/ml. The highest serum inhibitory dilution at peak level was frequently 1/64, and at trough level it was 1/16 to 1/32. The acute infection was satisfactorily controlled in all patients. Phlebitis, complicating intravenous therapy, in five out of eight patients, was the only side effect observed. Relapse of typhoid fever, as documented by positive blood culture, occurred in one patient 11 days after treatment course was completed. More extensive clinical studies are required before drawing any conclusions regarding the efficacy of cefazolin in acute enteric fever.
Authors:
M Uwaydah
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  10     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cefazolin / administration & dosage,  pharmacology,  therapeutic use*
Cephalosporins / therapeutic use*
Clinical Trials as Topic
Female
Humans
Male
Salmonella / drug effects
Salmonella Infections / drug therapy*
Chemical
Reg. No./Substance:
0/Cephalosporins; 25953-19-9/Cefazolin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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