Document Detail

Cefaclor in the treatment of otitis media with effusion.
MedLine Citation:
PMID:  3865493     Owner:  NLM     Status:  MEDLINE    
A randomized clinical trial in which 91 children with chronic OME participated was performed. Cefaclor 20 mg/kg body weight b.i.d. was given to the treated group (n = 46) during 10 days preceding the day appointed for surgery. The control group (n = 45) remained untreated. On the day scheduled for surgery 24 (52%) of the treated cases had healed, compared to 5 (11%) of the untreated cases, a significant difference (p less than 0.001). The long term effects showed that in the treated group 18 of the 24 primarily healed remained unoperated at a median follow-up period of 20 months. In the untreated group two of the five that originally resolved later relapsed and were subjected to surgery.
S Ernstson; M Anari
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  424     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-22     Completed Date:  1986-01-22     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
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MeSH Terms
Cefaclor / therapeutic use*
Cephalexin / analogs & derivatives*
Child, Preschool
Chronic Disease
Drug Evaluation
Follow-Up Studies
Otitis Media with Effusion / drug therapy*
Reg. No./Substance:
15686-71-2/Cephalexin; 53994-73-3/Cefaclor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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