Document Detail

Cdk5 kinase regulates the association between adaptor protein Bem1 and GEF Cdc24 in the fungus Ustilago maydis.
MedLine Citation:
PMID:  18682498     Owner:  NLM     Status:  MEDLINE    
Cyclin-dependent kinases from the Cdk5/Pho85 family are thought to play important roles in morphogenesis in species as diverse as yeast and humans. In the phytopathogenic fungus Ustilago maydis Cdk5 has a major role in the maintenance of cell polarity and virulence. This role seems to be related to the ability of the guanine-nucleotide exchange factor (GEF) Cdc24 to localize at the cell tips. However, the elements behind the Cdk5-dependent stabilization of Cdc24 at the cell poles are not well understood. Here we investigate the role of the adaptor protein Bem1 in polarity maintenance in U. maydis. We found that Bem1 and Cdc24 physically interact and colocalize at cell tips and that Cdk5 regulates this interaction. Our data suggest a method by which Cdk5 could regulate polar growth in this phytopathogenic fungus.
Isabel Alvarez-Tabarés; José Pérez-Martín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-05
Journal Detail:
Title:  Journal of cell science     Volume:  121     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-10-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2824-32     Citation Subset:  IM    
Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología-CSIC, 28049 Madrid, Spain.
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MeSH Terms
Adaptor Proteins, Signal Transducing / chemistry,  metabolism*
Amino Acid Sequence
Cell Nucleus / metabolism
Cell Polarity
Cyclin-Dependent Kinase 5 / metabolism*
Fungal Proteins / chemistry,  metabolism*
Guanine Nucleotide Exchange Factors / metabolism*
Molecular Sequence Data
Nuclear Export Signals
Protein Binding
Protein Transport
Subcellular Fractions / metabolism
Ustilago / cytology,  enzymology*,  growth & development
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Fungal Proteins; 0/Guanine Nucleotide Exchange Factors; 0/Nuclear Export Signals; EC Kinase 5

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