| APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. | |
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MedLine Citation:
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PMID: 20935501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets various substrates for proteolysis inside and outside of the cell cycle. The activation of APC/C is dependent on two WD-40 domain proteins, Cdc20 and Cdh1. While APC/Cdc20 principally regulates mitotic progression, APC/Cdh1 shows a broad spectrum of substrates in and beyond cell cycle. In the past several years, numerous biochemical and mouse genetic studies have greatly attracted our attention to the emerging role of APC/Cdh1 in genomic integrity, cellular differentiation and human diseases. This review will aim to summarize the recently expanded understanding of APC/Cdh1 in regulating biological function and how its dysfunction may lead to diseases. |
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Authors:
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Xinxian Qiao; Liyong Zhang; Armin M Gamper; Takeo Fujita; Yong Wan |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-10-11 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2011-03-02 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 3904-12 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Differentiation / physiology* G1 Phase / physiology Genome* Humans Mitosis / physiology Neoplasms / genetics, metabolism, pathology Signal Transduction Ubiquitin-Protein Ligase Complexes / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA115943/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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