Document Detail

Cdc6: a trifunctional AAA+ ATPase that plays a central role in controlling the G1-S transition and cell survival.
MedLine Citation:
PMID:  22908236     Owner:  NLM     Status:  Publisher    
Cdc6 is the AAA+ ATPase that assembles pre-replicative complexes on replication origins in eukaryotic chromosomes. Recently the same Cdc6 protein was found to exert two more functions in mammalian cells to promote cell proliferation and survival: ATP-dependent activation of p21(CIP1)- or p27(KIP1)-bound Cdk2-cyclin A/E complexes and obstruction of apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules. These findings not only redefined the biological role of mammalian Cdc6 but also led the discovery of entirely new mechanisms controlling Cdk2 activity and apoptosis. This review focuses on this multi-functional AAA+ ATPase and the newly discovered mechanisms by which it controls the G(1)-S transition and cell survival during proliferation.
Hiroto Okayama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Journal of biochemistry     Volume:  -     ISSN:  1756-2651     ISO Abbreviation:  J. Biochem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biochemistry and Molecular Biology Faculty and Graduate School of Medicine, The University of Tokyo Tokyo 113-0033, Japan.
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