Document Detail

CdTe-TiO2 nanocomposite: an impeder of bacterial growth and biofilm.
MedLine Citation:
PMID:  23579550     Owner:  NLM     Status:  Publisher    
The resurgence of infectious diseases and associated issues related to antibiotic resistance has raised enormous challenges which may possibly be confronted primarily by nanotechnology routes. One key need of critical significance in this context is the development of an agent capable of inhibiting quorum sensing mediated biofilm formation in pathogenic organisms. In this work we examine the possible use of a nanocomposite, CdTe-TiO2, as an impeder of growth and biofilm. In the presence of CdTe-TiO2, scanning electron microscopy (SEM) analysis shows exposed cells without the surrounding matrix. Confocal laser scanning microscopy shows spatially distributed fluorescence, a typical indication of an impeded biofilm, as opposed to the control which shows matrix-covered cells and continuous fluorescence, typical of biofilm formation. Quantitatively, the inhibition of biofilm was ∼57%. CdTe-TiO2 also exhibits good antibacterial properties against Gram positive and Gram negative organisms by virtue of the generation of reactive oxygen species inside the cells, reflected by a ruptured appearance in the SEM analysis.
Haribhau Gholap; Rajendra Patil; Prasad Yadav; Arun Banpurkar; Satishchandra Ogale; Wasudeo Gade
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-12
Journal Detail:
Title:  Nanotechnology     Volume:  24     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  195101     Citation Subset:  -    
National Chemical Laboratory (CSIR-NCL), Dr Homi Bhabha Road, Pashan, Pune 411008, India. Department of Physics, University of Pune, Pune 411007, India.
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