Document Detail

CdO Nanoparticle Toxicity on Growth, Morphology and Cell Division in Escherichia coli.
MedLine Citation:
PMID:  23137198     Owner:  NLM     Status:  Publisher    
This article deals with the toxicological study of synthesized CdO nanoparticles (NPs) on Escherichia coli. Characterization of the CdO NPs was done by DLS, XRD, TEM and AFM studies and the average size of NPs was revealed as 22±3 nm. The NPs showed bactericidal activity against E. coli. When NPs were added at mid-log phase of growth, complete growth inhibitory concentration was found 40 μg/mL. Bacterial cells changed morphological features to filamentous form with increasing CdO NPs exposure time, thereafter resulted in filamentation associated clumping. From AFM study severe damage of the cell surface was found in CdO NPs treated cells. CdO NPs were found to interfere with the expression level of two conserved cell division component, namely ftsZ and ftsQ in E. coli both at transcriptional and translational level. Interference of CdO NPs in proper septum formation without affecting the nucleoid segregation was also observed in confocal micrographs. The elevated intracellular oxidative stress due to CdO NPs exposure seems to be one of the reasons for the changes in cell morphology and expression of division proteins in E. coli.
Sk Tofajjen Hossain; Samir Kumar Mukherjee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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