Document Detail

Cavity foot ulcers in diabetic patients: a comparative study of cadexomer iodine ointment and standard treatment. An economic analysis alongside a clinical trial.
MedLine Citation:
PMID:  8800307     Owner:  NLM     Status:  MEDLINE    
Diabetic foot ulcers with exposure of tendon, muscle, or bone imply a high probability for deep infections and amputations. Delayed healing times are often described. The aim of this study was to compare the clinical effect and economic cost of cadexomer iodine with standard treatment in diabetic feet with cavity ulcers. Patients with deep, exudative foot ulcers were included in a 12-week open, randomised, comparative study. When ulcers stopped exudating, vaseline gauze was used in both groups until the end of the study. Costs were estimated for dressing material, staff and transportation. Clinically relevant improvement was seen in 12 patients treated with cadexomer iodine and in 13 patients treated with standard treatment. The average weekly cost was SEK 903 and SEK 1,421, respectively, of which the major part was costs for staff and transportation related to frequency of dressing changes. Treatment with cadexomer iodine ointment (Iodosorb) showed no clinical difference compared to topical treatment consisting of gentamicin solution, streptodornase/streptokinase, or dry saline gauze but was associated with considerably lower weekly treatment costs.
J Apelqvist; G Ragnarson Tennvall
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  76     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Department of Internal Medicine, University Hospital of Lund, Sweden.
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MeSH Terms
Anti-Bacterial Agents / economics,  therapeutic use
Cost-Benefit Analysis
Diabetic Foot / drug therapy*,  economics
Gentamicins / economics,  therapeutic use
Iodine Compounds / economics,  therapeutic use*
Streptodornase and Streptokinase / economics,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 0/Iodine Compounds; 0/Iodophors; 94820-09-4/cadexomer iodine; EC 3.-/Streptodornase and Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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