| Cavitation and vaporization threshold of perfluorocarbon droplets. | |
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MedLine Citation:
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PMID: 20330959 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Focused ultrasound therapy can be enhanced with microbubbles by thermal and cavitation effects. However, localization of treatment becomes difficult as bioeffects can occur outside of the target region. Spatial control of gas bubbles can be achieved with acoustic vaporization of perfluorocarbon droplets. This study was undertaken to determine the acoustic parameters for bubble production by droplet vaporization and how it depends on the acoustic conditions and droplet physical parameters. Droplets of varying sizes were sonicated in vitro with a focused transducer and varying frequencies and exposures. Simultaneous measurements of the vaporization and inertial cavitation thresholds were performed. The results show that droplets cannot be vaporized at low frequency without inertial cavitation occurring. However, the vaporization threshold decreased with increasing frequency, exposure, and droplet size. In summary, we have demonstrated that droplet vaporization is feasible for clinically relevant sized droplets and acoustic exposures. |
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Authors:
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Kelly Schad; Kullervo Hynynen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 127 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 1975 Citation Subset: IM |
Affiliation:
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Dept. Medical Biophys., Univ. Toronto, 2075 Bayview Ave., Toronto, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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