Document Detail

Cavitation and vaporization threshold of perfluorocarbon droplets.
MedLine Citation:
PMID:  20330959     Owner:  NLM     Status:  In-Data-Review    
Focused ultrasound therapy can be enhanced with microbubbles by thermal and cavitation effects. However, localization of treatment becomes difficult as bioeffects can occur outside of the target region. Spatial control of gas bubbles can be achieved with acoustic vaporization of perfluorocarbon droplets. This study was undertaken to determine the acoustic parameters for bubble production by droplet vaporization and how it depends on the acoustic conditions and droplet physical parameters. Droplets of varying sizes were sonicated in vitro with a focused transducer and varying frequencies and exposures. Simultaneous measurements of the vaporization and inertial cavitation thresholds were performed. The results show that droplets cannot be vaporized at low frequency without inertial cavitation occurring. However, the vaporization threshold decreased with increasing frequency, exposure, and droplet size. In summary, we have demonstrated that droplet vaporization is feasible for clinically relevant sized droplets and acoustic exposures.
Kelly Schad; Kullervo Hynynen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  127     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1975     Citation Subset:  IM    
Dept. Medical Biophys., Univ. Toronto, 2075 Bayview Ave., Toronto, ON, Canada.
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