Document Detail

Cavernous sinus syndrome: a series of 126 patients.
MedLine Citation:
PMID:  17873757     Owner:  NLM     Status:  MEDLINE    
The etiology of cavernous sinus syndrome (CSS) remains difficult to determine in spite of the development of neuroimaging techniques. We conducted the current study to identify clinical and imaging features that allow a reliable approach to the etiologic diagnosis of patients with CSS. We studied a consecutive series of 126 patients with CSS, defined as involvement of 2 or more of the third, fourth, fifth (V1, V2), or sixth cranial nerves, or involvement of only 1 of them in combination with a neuroimaging-confirmed lesion in the cavernous sinus. Tumors were the most common cause of CSS (80 patients). All patients with optic nerve involvement had a tumor. No patient with a normal MRI had a tumor. The lack of pain during the course of the disease (odds ratio [OR], 0.58; 95% confidence intervals [CI], 0.06-0.40), V2 involvement (OR, 12.17; 95% CI, 2.98-49.71), and male sex (OR, 3.2; 95% CI, 1.31-8.14) were independently associated with the presence of a tumor. Pain at the onset of disease (OR, 12.09; 95% CI, 3.14-46.50) and third cranial nerve involvement (OR, 4.9; 95% CI, 1.01-24.60) were independently associated with Tolosa-Hunt syndrome.
Susana Fernández; Oscar Godino; Sergio Martínez-Yélamos; Edilia Mesa; Jordi Arruga; José María Ramón; Juan José Acebes; Francisco Rubio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine     Volume:  86     ISSN:  0025-7974     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2008-03-21     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-81     Citation Subset:  AIM; IM    
Department of Neurology, University Hospital of Bellvitge, IDIBELL, Barcelona, Spain.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Cavernous Sinus / pathology*
Cranial Nerve Diseases / diagnosis*,  etiology*,  pathology,  radiography
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Odds Ratio
Proportional Hazards Models
Spinal Puncture
Tomography, X-Ray Computed

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