Document Detail


Cavernous malformations.
MedLine Citation:
PMID:  20561497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cavernous malformations (CMs) are vascular lesions found in the central nervous system (CNS) and throughout the body and have been called cavernomas, cavernous angiomas, and cavernous hemangiomas. This article discusses the epidemiology, natural history, diagnosis, treatment and follow-up of children who are found to harbor these lesions. CMs affect children by causing hemorrhage, seizure, focal neurologic deficits, and headache. Diagnosis is best made with magnetic resonance imaging. Patients with multiple lesions should be referred for genetic evaluation and counseling. Individuals with symptomatic, growing, or hemorrhagic malformations should be considered for surgical resection. Close follow-up after diagnosis and treatment is helpful to identify lesion progression or recurrence.
Authors:
Edward R Smith; R Michael Scott
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery clinics of North America     Volume:  21     ISSN:  1558-1349     ISO Abbreviation:  Neurosurg. Clin. N. Am.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9008004     Medline TA:  Neurosurg Clin N Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-90     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurosurgery, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. edward.smith@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Cerebral Arteries / abnormalities*,  pathology,  surgery*
Cerebral Hemorrhage / etiology,  prevention & control,  surgery
Child
Diagnosis, Differential
Hemangioma, Cavernous, Central Nervous System / pathology*,  radiography,  surgery*
Humans
Magnetic Resonance Imaging / standards
Neurosurgical Procedures / methods*,  standards*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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