Document Detail

Cavernous malformation of the optic nerve mimicking optic neuritis.
MedLine Citation:
PMID:  20351573     Owner:  NLM     Status:  MEDLINE    
A 30-year-old woman developed acute visual loss and optic disc elevation in the left eye after breastfeeding her second son. The initial diagnosis was optic neuritis. However, MRI showed a lesion in left intraorbital and intracanalicular optic nerve and several cerebral lesions with imaging features of cerebral cavernous malformations (CCMs). Genetic testing was positive for abnormalities known to predispose to CCMs in the patient and her father, who also showed MRI evidence of CCMs. During a 44-month follow-up period in which no intervention took place, the patient's vision in the affected eye fluctuated but eventually became extinguished. Serial MRIs did not always show lesion changes that explained the visual deterioration. In familial CCM, pregnancy might be a "second hit" to genetically predisposed tissue.
Alfonso Cerase; Rossella Franceschini; Stefania Battistini; Ignazio Maria Vallone; Silvana Penco; Carlo Venturi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  30     ISSN:  1536-5166     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-31     Citation Subset:  IM    
Unit of Neuroimaging and Neurointervention, Department of Neurosciences, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte," Viale Mario Bracci, 16, 53100 Siena, Italy.
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MeSH Terms
Blindness / etiology
Brain / pathology,  physiopathology
Diagnosis, Differential
Diagnostic Errors / prevention & control
Hemangioma, Cavernous, Central Nervous System / diagnosis*,  physiopathology
Magnetic Resonance Imaging
Optic Nerve / pathology*,  physiopathology
Optic Nerve Diseases / diagnosis*,  physiopathology
Optic Neuritis / diagnosis*,  physiopathology
Pregnancy Complications / diagnosis,  physiopathology
Vision, Low / etiology*

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