Document Detail

Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.
MedLine Citation:
PMID:  8921647     Owner:  NLM     Status:  MEDLINE    
A 2-day-old newborn was treated with tolazoline for persistent pulmonary hypertension due to meconium aspiration syndrome. Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred. After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values. Tolazoline induces a dilatation of the pulmonary vascular system by stimulating H2 receptors. Cimetidine, an H2 blocker, may partially abolish the effect of tolazoline. However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.
C B Huang; S C Huang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital     Volume:  19     ISSN:  -     ISO Abbreviation:  Changgeng Yi Xue Za Zhi     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-19     Completed Date:  1996-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9809559     Medline TA:  Changgeng Yi Xue Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  268-71     Citation Subset:  IM    
Department of Pediatrics, Chang Gung Children's Hospital, Kaohsiung, Taiwan, R.O.C.
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MeSH Terms
Cimetidine / adverse effects*
Drug Interactions
Gastrointestinal Hemorrhage / prevention & control*
Histamine H2 Antagonists / adverse effects*
Infant, Newborn
Persistent Fetal Circulation Syndrome / drug therapy*
Tolazoline / adverse effects*
Vasodilator Agents / adverse effects*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Vasodilator Agents; 51481-61-9/Cimetidine; 59-98-3/Tolazoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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