| Causes of, and therapeutic approaches for, proton pump inhibitor-resistant gastroesophageal reflux disease in Asia. | |
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MedLine Citation:
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PMID: 21180528 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Proton pump inhibitors (PPIs) are the most widely used drugs for treatment of gastroesophageal reflux disease. However, approximately 20% of patients with reflux esophagitis and 40% of those with nonerosive reflux diseases complain of troublesome symptoms, even during treatment with PPIs. In patients with reflux esophagitis, dose escalation and co-administration with a histamine H(2)-receptor antagonist are potential approaches, since the major cause of PPI resistance is incomplete suppression of gastric acid secretion. On the other hand, for patients with nonerosive reflux disease, switching from PPIs to pain modulators is often necessary for improvement of symptoms, since 25% of patients with nonerosive reflux disease have symptoms not caused by gastroesophageal acid reflux. Therapeutic approaches for PPI-resistant patients with reflux esophagitis and nonerosive reflux diseases are considered according to pathogenesis. |
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Authors:
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Yoshikazu Kinoshita; Shunji Ishihara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic advances in gastroenterology Volume: 1 ISSN: 1756-283X ISO Abbreviation: Therap Adv Gastroenterol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-07-14 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 101478893 Medline TA: Therap Adv Gastroenterol Country: England |
Other Details:
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Languages: eng Pagination: 191-9 Citation Subset: - |
Affiliation:
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Department of Gastro-enterology and Hepatology, Shimane University School of Medicine, Izumo, Shimane, Japan kinosita@med.shimane-u.ac.jp. |
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