Document Detail

Causes of pure aortic regurgitation in patients having isolated aortic valve replacement at a single US tertiary hospital (1993 to 2005).
MedLine Citation:
PMID:  16864725     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The causes of aortic regurgitation (AR) severe enough to warrant aortic valve replacement (AVR) have received little attention in the last 20 years. METHODS AND RESULTS: We analyzed the causes of pure AR in 268 patients > 20 years of age having isolated AVR at Baylor University Medical Center from 1993 to 2005 that was unassociated with mitral stenosis, mitral valve replacement, or a previous operation involving a cardiac valve or ascending aorta. In 122 patients (46%), the AR resulted from a problem with the aortic valve: congenital malformation unassociated with infective endocarditis, 66 patients (54%); infective endocarditis, 46 patients (38%; 15 with bicuspid valves); probable rheumatic heart disease, 8 patients (6%); and miscellaneous, 2 patients (2%). In the other 146 patients (54%), the AR was the consequence of a condition affecting the ascending aorta: dissection, 28 patients (19%); the Marfan syndrome or its forme fruste variety, 15 patients (10%); aortitis, 12 patients (8%), and in the remaining 91 patients (62%), the cause of the AR was not determined. This latter group was the oldest (mean age 66 years), 83 (91%) had hypertension, 26 (29%) had small calcific deposits in the valve cusps, and 46 (51%) had simultaneous coronary artery bypass grafting. CONCLUSIONS: The causes of pure AR severe enough to warrant isolated AVR are diverse. The most common category in this study was "cause unclear."
William Clifford Roberts; Jong Mi Ko; Timothy Richard Moore; William Hampton Jones
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Publication Detail:
Type:  Journal Article     Date:  2006-07-24
Journal Detail:
Title:  Circulation     Volume:  114     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-9     Citation Subset:  AIM; IM    
Department of Pathology, Division of Cardiology, Baylor Heart & Vascular Institute, Baylor University Medical Center, 3500 Gaston Ave, Dallas, TX 75246, USA.
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MeSH Terms
Aged, 80 and over
Aneurysm, Dissecting / complications,  pathology,  physiopathology
Aortic Valve / pathology,  physiopathology,  surgery*
Aortic Valve Insufficiency / etiology*,  physiopathology,  surgery*
Aortitis / complications,  pathology,  physiopathology
Coronary Artery Bypass / adverse effects
Endocarditis, Bacterial / complications,  pathology,  physiopathology
Heart Defects, Congenital / complications,  pathology,  physiopathology
Heart Valve Prosthesis / statistics & numerical data*
Hospitals, University / statistics & numerical data*
Hypertension / pathology,  physiopathology
Marfan Syndrome / complications,  pathology,  physiopathology
Middle Aged
Mitral Valve Stenosis / complications,  pathology,  physiopathology
Retrospective Studies
Rheumatic Heart Disease / complications,  pathology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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