Document Detail


Causes and predictors of death in Brazilian lupus patients.
MedLine Citation:
PMID:  22461184     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The objective of this study is to determine the causes and predictors of death in systemic lupus erythematosus (SLE) patients. Causes of death were defined based on death certificates, medical records, and information collected from doctors and relatives. Possible variables predicting mortality were assessed by Kaplan-Meier and Cox regression methods. The multivariate model was validated using the bootstrap method, and the hazard ratios were adjusted according to the shrinkage coefficient. One hundred eighty-one patients were included, and two patients were lost to follow-up. The median (IR) age at T (0) and disease duration of the 179 patients were 26.7 (21.8-34.6) and 8.2 (4.3-12.4) years, respectively. After a median (IR) follow-up of 3.3 (3.1-3.5) years, 13 (7.3 %) patients died due to end-organ failure (5), infection (5), disease activity (1), and atherosclerotic cardiovascular disease (CVD) (1). The cause of mesenteric ischemia in one patient could not be determined. Predictors of mortality collected at T (0) were the following: nephritis, chronic kidney disease, antiphospholipid syndrome (APS), higher modified SLEDAI-2k, higher damage index score, intravenous cyclophosphamide use, higher daily dose of prednisone, and higher systolic blood pressure. Independent predictors of mortality were higher damage index score (HR: 1.40; 95 % CI: 1.08-1.82), cyclophosphamide use (HR: 3.80; 95 % CI: 1.13-12.77), and APS diagnosis (HR: 3.82; 95 % CI: 1.07-13.59). This paper presents a high frequency of late mortality in lupus patients due to the SLE itself and infection. This result is not in agreement with the initial proposed bimodal pattern of lupus mortality, nor is it in agreement with the high frequency of CVD as a cause of death in developed countries. The most important predictors of death were related to the lupus itself.
Authors:
Rosa Weiss Telles; Cristina Costa Duarte Lanna; Fabiana Lemos Souza; Luciana Andrade Rodrigues; Rodrigo Citton Padilha Reis; Antonio Luiz Ribeiro
Related Documents :
1357564 - Serotonergic pathology is not widespread in alzheimer patients without prominent aggres...
7644044 - The neuropsychological pattern of corticobasal degeneration: comparison with progressiv...
17071924 - Demographic, neurological and behavioural characteristics and brain perfusion spect in ...
2001184 - Assessing the severity of dementia. patient and caregiver.
2195134 - Characteristics of patients with multiple personality and dissociative disorders on psy...
11139154 - Staphylococcus aureus and other bacteremias in hemodialysis patients: antibiotic therap...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-30
Journal Detail:
Title:  Rheumatology international     Volume:  -     ISSN:  1437-160X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Hospital das Clínicas, Belo Horizonte, Minas Gerais, Brazil, rwtelles@uol.com.br.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Moxibustion for the treatment of osteoarthritis: a systematic review and meta-analysis.
Next Document:  Circulating angiopoietin and Tie-2 levels in systemic sclerosis.