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Causes of permanent childhood hearing impairment.
MedLine Citation:
PMID:  21271598     Owner:  NLM     Status:  Publisher    
INTRODUCTION: The causes of Permanent Childhood Hearing Impairment (PCHI) are often quoted as being hereditary in 50%, acquired in 25%, and unknown in 25% of cases. Interest in the causes of PCHI has grown recently due to increasing diagnostic possibilities. We investigated the evidence for the reported distribution of these causes. METHODS: Population-based study and a systematic review. Inclusion criteria for population-based study: children born between 2003 and 2005, resident in The Netherlands at birth, known at an Audiology Center with PCHI at the age of 3-5 years. The causes of PCHI were determined prospectively by detection of congenital cytomegalovirus on dried blood spots and/or genetic diagnostic investigations in addition to reviewing data from medical records. A systematic review was carried out using three terms (hearing loss, infant, and etiology) and limited to articles published between January 1997 and July 2009. Main outcome measures were: the (weighted) proportions of the various causes of PCHI following diagnostic investigations. RESULTS: In the study-population (n = 185) a hereditary cause was found in 38.9%, acquired cause in 29.7%, miscellaneous cause in 7.1%, and the cause remained unknown in 24.3%. The systematic review of the literature (n = 9 articles) resulted in a weighted mean of 30.4% hereditary, 19.2% acquired, and 48.3% unknown causes of PCHI. DISCUSSION: The systematic review and the results of the population-based study provided little support for the generally accepted distribution of causes of PCHI. Laryngoscope, 2011.
Anna M H Korver; Ronald J C Admiraal; Sarina G Kant; Friedo W Dekker; Capi C Wever; Henricus P M Kunst; Johan H M Frijns; Anne Marie Oudesluys-Murphy;
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Publication Detail:
Journal Detail:
Title:  The Laryngoscope     Volume:  121     ISSN:  1531-4995     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  -    
Other Details:
Languages:  ENG     Pagination:  409-416     Citation Subset:  -    
Copyright Information:
Copyright © 2010 The American Laryngological, Rhinological, and Otological Society, Inc.
From the Willem-Alexander Children and Youth Center , Subdepartment of Social Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
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