Document Detail

Causes of infertility in men with Down syndrome.
MedLine Citation:
PMID:  21806650     Owner:  NLM     Status:  Publisher    
Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate that the causes may be hormonal deficits, morphological alterations of the gonads, abnormal spermatogenesis, psychological and social factors related to the mental retardation. It is obvious that the extra chromosome 21 has a detrimental direct and indirect effect on the reproductive capacity of the affected male patient. But the definite cause of the insufficient and inadequate spermatogenesis remains to be discovered.
K Stefanidis; P Belitsos; A Fotinos; N Makris; D Loutradis; A Antsaklis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-2
Journal Detail:
Title:  Andrologia     Volume:  -     ISSN:  1439-0271     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Verlag GmbH.
 1st Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Athens, Greece  Department of Biology, Wesleyan University, Middletown, CT, USA.
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