Document Detail

Causes for hospitalization and death in Iranian patients with ?-Thalassemia major.
MedLine Citation:
PMID:  20795770     Owner:  NLM     Status:  In-Data-Review    
There are limited studies that have focused on the causes for hospitalization as an indicator of morbidity in patients with ?-thalassemia major (BTM). A cross-sectional study was conducted to determine the main causes for hospitalization and death in hospitalized BTM patients in a referral hospital in Shiraz, southern Iran. During a 5-year period, 555 BTM patients were admitted to the hospital, of which 390 (67.7%) were 10 to 20 years of age. The most frequent causes for hospitalization were splenectomy (23%), heart failure (22.6%), liver biopsy (22.2%), uncontrolled diabetes (10.9%), arrhythmia (7.2%), cholecystectomy (3.8%), hypoparathyroidism (2.1%), and sepsis (2%). Of the hospitalized patients, 65 (11%), with a mean age of 16.1 ? 4.2 years, died. The most common causes of death were cardiomyopathy (72.3%), infections (17%), malignancies (3.1%), and cerebrovascular accidents (3.1%). Survival of our patients was less than in developed countries and cardiac complications were the most common cause of mortality and morbidity in these patients. Regarding the key role of iron chelation in prevention of different complications in BTM, correction of iron chelation regimen should be well considered.
Masood Bazrgar; Farah Peiravian; Fatemeh Abedpour; Mehran Karimi
Publication Detail:
Type:  Journal Article     Date:  2010-08-26
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  28     ISSN:  1521-0669     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  134-9     Citation Subset:  IM    
Genetics Department of Genetics, Royan Institute for Reproductive Medicine, Iranian Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran; and Human Genetic Research Group, ACECR, Fars Province Branch, Shiraz, Iran.
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