| Causes of death and re-hospitalization in cardiogenic shock. | |
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MedLine Citation:
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PMID: 17453536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In cardiogenic shock, causes of death usually are cardiac. However, a systemic inflammatory response syndrome may influence outcome. METHODS: SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK? (SHOCK) Trial patients (n = 302) were analyzed regarding cause of death and re-hospitalization. RESULTS: Deaths (n = 180) occurred < or =30 days in 86% and >30 days in 14%. Known causes of death < or =30 days were cardiac in 88% (37% arrhythmic) and non-cardiac in 12% (29% septic). Non-cardiac deaths < or =30 days occurred later (206 [91,394] versus 41 [15,156] h, P<0.01) and were more frequently associated with signs of inflammation (43 versus 12%, P = 0.01) than cardiac deaths < or =30 days. Known causes of in-hospital death >30 days (n = 19) were cardiac in 58% and non-cardiac in 42%. Among deaths < or =30 days systemic vascular resistance index was higher (2,666+/-1,063 versus 2,090+/-731 dynes.sec.cm(-5) m(2), P = 0.05) than among deaths >30 days. Among the 116 survivors of the initial hospitalization with data available, 52 (45%) were readmitted, most of which due to heart failure (n = 22, 42%) and myocardial ischemia (n = 16, 31%). Conclusions: In CS, early deaths < or =30 days are mainly cardiac. Non-cardiac deaths are associated with signs of inflammation. In survivors of the initial hospitalization, re-hospitalizations are due to heart failure and myocardial ischemia. |
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Authors:
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Raban V Jeger; Susan F Assmann; Loran Yehudai; Krishnan Ramanathan; Michael E Farkouh; Judith S Hochman |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acute cardiac care Volume: 9 ISSN: 1748-2941 ISO Abbreviation: Acute Card Care Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-24 Completed Date: 2007-06-13 Revised Date: 2009-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101276603 Medline TA: Acute Card Care Country: Sweden |
Other Details:
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Languages: eng Pagination: 25-33 Citation Subset: IM |
Affiliation:
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Cardiovascular Clinical Research Center, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cause of Death* Coronary Angiography Female Humans Male Middle Aged Myocardial Infarction / complications*, surgery* Myocardial Revascularization / methods Patient Readmission / statistics & numerical data* Risk Assessment Risk Factors Shock, Cardiogenic / etiology*, mortality* Statistics, Nonparametric Survival Analysis Systemic Inflammatory Response Syndrome / complications*, etiology, mortality Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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HL 49970/HL/NHLBI NIH HHS; HL 50020/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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