Document Detail

Causes of death in patients with Huntington's disease and in unaffected first degree relatives.
MedLine Citation:
PMID:  1479606     Owner:  NLM     Status:  MEDLINE    
Causes of death were examined from death certificates for 395 Danish subjects with Huntington's disease (HD) and for 282 unaffected sibs and compared with the causes of death in the general Danish population. For both the HD subjects and the sibs, pneumonia and cardiovascular diseases were the most frequent primary causes of death. Suicides accounted for 5.6% of all deaths among the HD subjects and, unexpectedly, for 5.3% among the sibs, some of whom may have been carriers of the HD gene. Both were significantly higher than the corresponding frequency of 2.7% in the general Danish population, but there was no evidence of differences in the age specific proportions for the HD subjects and for the sibs compared to the general population. Some accidents leading to death in the sibs may have been hidden suicides. The rate of cancer was low for the HD patients, being only 5.3% compared with 31.2% for the sibs. Neurological diseases were reported with an increased frequency in the HD patients compared to the general population, 6% v 1%.
S A Sørensen; K Fenger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical genetics     Volume:  29     ISSN:  0022-2593     ISO Abbreviation:  J. Med. Genet.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-09     Completed Date:  1993-02-09     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2985087R     Medline TA:  J Med Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  911-4     Citation Subset:  IM    
Institute of Medical Genetics, University of Copenhagen, Denmark.
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MeSH Terms
Accidents / statistics & numerical data
Cardiovascular Diseases / mortality
Cause of Death
Child, Preschool
Denmark / epidemiology
Huntington Disease / mortality*
Middle Aged
Nervous System Diseases / mortality
Pneumonia / mortality
Risk Factors
Suicide / statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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