Document Detail


Causes of death in autosomal dominant polycystic kidney disease.
MedLine Citation:
PMID:  7579053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the causes of death in autosomal dominant polycystic kidney disease (ADPKD) patients and to examine whether the extrarenal manifestations of ADPKD influence the causes of death, the medical records of 129 patients who died between 1956 and 1993 were reviewed; 58% of the 129 patients had an autopsy performed. Seventy-seven percent died after reaching ESRD. The mean age at death increased from 51 yr for those who died before 1975 to 59 yr for those who died after 1975, reflecting the introduction of renal replacement therapies. The most common cause of death before 1975 was infection (30%), followed by uremia (28%) and cardiac disease (21%); after 1975, these were cardiac disease (36%) and infection (24%). Infection was equally prevalent before and after 1975, presenting as sepsis in 94% and directly relating to ADPKD in 47% of these patients. Underlying factors for cardiac death were cardiac hypertrophy, seen in 89% of all autopsied patients, and coronary artery disease, seen in 81%. A neurologic event was the cause of death in 12% of patients; these were ruptured intracranial aneurysm in 6%, hypertensive intracranial hemorrhage in 5%, and ischemic stroke in 1%. The mean age of those who died of ruptured intracranial aneurysm was 37 yr. No patient died of renal cancer. Liver cysts were the most common extrarenal manifestation, seen in 70% of the autopsied cases; cysts in other organs were very rare. Colonic diverticula were found in 21%. Thus, the renal and extrarenal manifestations of ADPKD are important contributors to morbidity and mortality.
Authors:
G M Fick; A M Johnson; W S Hammond; P A Gabow
Related Documents :
3114333 - Cardiovascular effects of imipramine and bupropion in depressed patients with congestiv...
2029013 - Thallium stress testing does not predict cardiovascular risk in diabetic patients with ...
16794643 - Serum fructosamine in the assessment of glycaemic status in patients with sickle cell a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  5     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2048-56     Citation Subset:  IM    
Affiliation:
University of Colorado Health Sciences Center, Denver 80262, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Autopsy
Cardiovascular Diseases / etiology,  mortality*
Cause of Death*
Colorado / epidemiology
Cysts / epidemiology,  genetics
Death Certificates
Diverticulum / epidemiology,  genetics
Female
Humans
Infection / etiology,  mortality*
Liver Diseases / epidemiology,  genetics
Longevity
Male
Medical Records
Neoplasms / mortality
Pancreatic Cyst / epidemiology,  genetics
Polycystic Kidney, Autosomal Dominant* / complications,  mortality
Retrospective Studies
Uremia / etiology,  mortality*
Grant Support
ID/Acronym/Agency:
5 P01 DK34039/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dietary protein restriction, blood pressure control, and the progression of polycystic kidney diseas...
Next Document:  Effect of atrial natriuretic peptide on renal and vascular permeability in diabetes mellitus.