Document Detail

Causes of death from myocardial infarction before and after thrombolysis era: a pathologic study.
MedLine Citation:
PMID:  8942226     Owner:  NLM     Status:  MEDLINE    
One hundred and sixty-eight out of 296 patients who died of acute myocardial infarction (AMI) in the Coronary Care Unit were studied to assess the cause of death. Twenty-two of them had received thrombolytic therapy. The mean age of these patients was 64.3 +/- 18.2 years. One hundred and eight subjects were male and 60 were female. One hundred and nine cases (64.8%) showed, at postmortem examination, histopathologic alterations due to acute myocardial infarction (AMI). Death was due to heart failure in 35.8%, cardiogenic shock in 20% and ventricular arrhythmia in 44%. The other 59 patients died from complications superimposed upon AMI: reinfarction (23.7%), heart rupture (40.7%), myocardial fibrosis and reinfarction (18.6%), and cerebral infarction (17%). Two of these patients also showed massive pneumonia. In those subjects who had received thrombolytic therapy, a broad spectrum of arrhythmic and haemorrhagic complications were seen (68%). Four causes of death were seen in the subjects studied: AMI, superimposed cardiac complications, side-effects of thrombolytic treatment, and non-cardiac causes. Patients who did not receive thrombolysis mechanical events eg heart failure, characterized their deaths. In subjects who had received thrombolytic therapy, arrhythmic and haemorrhagic were widely observed.
A Leone
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  37     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-01-07     Completed Date:  1997-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  270-2     Citation Subset:  IM    
City Hospital, Division di Medicine, Ospedale di Pontremoli, Pontremoli (MS), Italy.
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MeSH Terms
Age Distribution
Aged, 80 and over
Hospital Mortality*
Middle Aged
Myocardial Infarction* / drug therapy,  mortality,  pathology
Sex Distribution
Survival Rate
Thrombolytic Therapy*

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