| Causes of death by level of dependency at 6 months after ischemic stroke in 3 large cohorts. | |
| | |
MedLine Citation:
|
PMID: 19265057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: We assessed the influence of functional status at 6 months after ischemic stroke on cause of death during long-term follow-up in 3 prospective cohorts. METHODS: The cohorts were 7710 patients from the Oxfordshire Community Stroke Project, Lothian Stroke Register, and International Stroke Trial. Functional status was assessed at 6 months after stroke onset. Causes of death were identified from death certificates, and were also classified into "stroke-related" or "other" causes. We calculated the relative risk with 95% CI to assess the association between dependency level and cause of death. We also performed a multivariable regression analysis to adjust for other relevant factors. RESULTS: Six months after stroke onset 5961 (78%) patients were still alive. At the end of follow-up period, 1620 (47%) patients who were functionally dependent at 6 months after stroke onset had died vs 711 (28%) independent patients. Dependent patients had a relative risk of dying from stroke of 1.70 (95% CI, 1.44-2.00) compared to independent patients. Overall, dependent patients had a relative risk of 1.68 (95% CI, 1.49-1.91) of dying from stroke-related causes. Dependency remained significantly (P<0.01) associated with stroke-related causes of death in a multivariable regression analysis. CONCLUSIONS: Stroke-related deaths continue to be a problem during the years after an ischemic stroke, especially in patients who are functionally dependent at 6 months after onset. Better acute treatments to reduce dependency and adequate secondary prevention remain high priorities. |
| | |
Authors:
|
Karsten Bruins Slot; Eivind Berge; Peter Sandercock; Steff C Lewis; Paul Dorman; Martin Dennis; ; ; |
Related Documents
:
|
19834397 - Safety, effectiveness, and practicality of endovascular therapy within the first 3 hour... 19573877 - Recanalization of the mca should play an important role in dramatic recovery after t-pa... 3284017 - Antiplatelet agents in the secondary prevention of stroke: meta-analysis of the randomi... 9357457 - Prevention of postoperative thrombotic stroke after carotid endarterectomy: the role of... 19795027 - Computed tomography-guided radiofrequency ablation of hepatocellular carcinoma: treatme... 22136877 - Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-05 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 40 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-28 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 1585-9 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Ullevaal University Hospital, Oslo, Norway. karsten.bruins.slot@medisin.uio.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Brain Ischemia / complications* Cause of Death Cohort Studies Female Follow-Up Studies Great Britain / epidemiology Humans Male Regression Analysis Sex Factors Stroke / etiology*, mortality* Survival |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prior statin use, intracranial hemorrhage, and outcome after intra-arterial thrombolysis for acute i...
Next Document: Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama stu...