| Causes and consequences of low grade endotoxemia and inflammatory diseases . | |
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MedLine Citation:
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PMID: 23277084 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Increasing clinical observations reveal that persistent low-grade inflammation is associated with the pathogenesis of severe chronic diseases such as atherosclerosis, diabetes, and aging-related neurological diseases. Intriguingly, low levels of circulating Gram-negative bacterial endotoxin lipopolysaccharide (LPS) appear to be one of the key culprits in provoking a non-resolving low-grade inflammation. Adverse life styles, chronic infection, and aging can all contribute to the rise of circulating endotoxin levels and lead to low-grade endotoxemia. As a consequence, low-grade endotoxemia may skew host immune environment into a mild non-resolving pro-inflammatory state, which eventually leads to the pathogenesis and progression of inflammatory diseases. This review aims to highlight the recent progress in the causes and consequences of low-grade endotoxemia, as well as the emerging molecular mechanisms responsible. |
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Authors:
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Trevor G Glaros; Samantha Chang; Elizabeth A Gilliam; Urmila Maitra; Hui Deng; Liwu Li |
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Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 5 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 754-65 Citation Subset: IM |
Affiliation:
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Life Science 1 Building, Washington Street, Department of Biology, Virginia Tech, Blacksburg, VA 24061. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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