| Causes of abortion on New Zealand dairy farms with a history of abortion associated with Neospora caninum. | |
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MedLine Citation:
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PMID: 22175426 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: To investigate the cause of abortion in cows from farms with a history of abortion associated with Neospora caninum. METHODS: Cows and primiparous heifers (n = 2,246) that were enrolled in a clinical trial of a vaccine for N. caninum, and 403 cows and heifers that conceived >6 weeks after the planned start of mating (PSM), were monitored for abortion on five dairy farms with a history of abortion associated with N. caninum. When abortion was detected the fetus and/or placenta were submitted for histopathological examination and maternal paired sera were collected for the detection of antibodies to N. caninum using the indirect fluorescent antibody test (IFAT), bovine viral diarrhoea virus (BVDV) using ELISA, and Leptospira spp. using the microscopic agglutination test (MAT). RESULTS: At the start of the clinical trial, 189/1,760 (10.7%) of cows and 61/486 (12.6%) of heifers had IFAT titres ≥1:200 for N. caninum. Abortions were detected in 111 (4.9%) enrolled and 37 (9.2%) non-enrolled cows and heifers. The relative risk of abortion was 4.21 (95% CI 2.92-6.08) times greater in enrolled animals that were seropositive to N. caninum than seronegative animals (p < 0.01). Among all animals, histopathological lesions suggestive of protozoal abortion were seen in nine, and of bacterial infection in 15, of the 40 cases where the fetus and/or placenta were recovered. IFAT titres for N. caninum ≥1:1,000 were detected in 66 cows at abortion, including 7/9 cases where there were fetal lesions indicative of N. caninum infection. In nine cows that aborted, there was evidence of seroconversion to BVDV and eight cows had MAT titres for Leptospira spp. ≥1:200. Histopathology revealed dual infectious aetiologies in two cases and, in another 17 cases, there was serological evidence of recent exposure to a second infectious agent capable of causing abortion in conjunction with N. caninum lesions in the fetus or fetal bacteraemia. CONCLUSIONS: Multiple infectious aetiologies occur at herd-level and in individual cows on farms with a history of abortion associated with N. caninum. A diagnosis of abortion due to N. caninum infection was made in 9/34 (26.5%) cases where fetal histopathology was undertaken. CLINICAL RELEVANCE: Thorough and ongoing diagnostic investigations should be undertaken in herds with higher than expected abortion losses to identify all causative agents as control measures could be implemented that may also reduce the risk of abortion in cows infected with N. caninum. |
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Authors:
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Jf Weston; C Heuer; Tj Parkinson; Nb Williamson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: New Zealand veterinary journal Volume: 60 ISSN: 0048-0169 ISO Abbreviation: N Z Vet J Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0021406 Medline TA: N Z Vet J Country: New Zealand |
Other Details:
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Languages: eng Pagination: 27-34 Citation Subset: IM |
Affiliation:
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a Institute of Veterinary, Animal and Biomedical Sciences, Massey University , Private Bag 11222 , Palmerston , North 4442 , New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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