Document Detail


Causes of Delivery and Outcomes of Very Preterm Twins Stratified to Zygosity.
MedLine Citation:
PMID:  22853920     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The increasing rates of preterm birth among twins implicate that solid data on associated risks and outcomes are required. Assessment of zygosity is often based on clinical criteria (evaluation of placenta; same gender, birth weight discordance as surrogate criteria for monochorionic/monozygotic twins). The aim of this study was to compare clinical versus genetic assessment of zygosity and to compare causes of preterm delivery as well as outcome data of very-low-birth-weight (VLBW; birth weight <1,500 g) twins stratified to zygosity. In a multicenter study, we selected n = 176 sets of same gender twins and determined zygosity genetically. In a subgroup of 123 sets of twins, the attending physicians at the study centers were asked to document the parameter 'zygosity' (monozygotic/dizygotic) on the basis of their clinical judgment. Concordance between genetic and clinical assessment was 62.7% for monozygotic twins and 88.9% for dizygotic twins, respectively. Outcome parameters (death, BPD, ROP, NEC, IVH) were comparable in both groups. Genetically dizygotic twins were significantly more often born due to intrauterine infection (33% vs. 20% in monozygotic twins, p < .01) and antenatal antibiotics were more frequently given to mothers of dizygotic twins (62% vs. 47% in monozygotic twins, p < .01). Obstetric complications such as twin-twin-transfusion-syndrome were only seen in monozygotic twins as expected. The unexpected increase of antenatal antibiotic treatment and birth due to intrauterine infection in dizygotic twins should be confirmed in additional VLBW twin-cohorts.
Authors:
Juliane Spiegler; Christoph Härtel; Lena Schulz; Nicole von Wurmb-Schwark; Thomas Hoehn; Angela Kribs; Helmut Küster; Jens Siegel; Christian Wieg; Jan Weichert; Egbert Herting; Wolfgang Göpel;
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  15     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  532-536     Citation Subset:  -    
Affiliation:
Department of Pediatrics, University Hospital of Schleswig-Holstein, Luebeck, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  EMS Response to an Airliner Crash.
Next Document:  Coping profiles characterize individual flourishing, languishing, and depression.