Document Detail

Cause of death in multiple endocrine neoplasia type 1.
MedLine Citation:
PMID:  8099273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Little data are available on the natural history of untreated multiple endocrine neoplasia type 1 (MEN-1). These data are essential in deciding treatment that may carry significant morbidity. We determined the causes of death in a large MEN-1 kindred with data available over a period of 130 years. Most cases were unrecognized as MEN-1 at the time of patient's death. DESIGN: Retrospective study of recorded medical data from 1861 to 1991. PATIENTS: One hundred fifty-nine deaths occurred, of which 46 were in individuals classified as "highly probable" of having MEN-1. RESULTS: Of 46 deaths in those classified as "highly probable" of having MEN-1, 20 (43.5%) died of a recognized complication of MEN-1 (12 of malignant neoplasms, six of renal calculi, and two of peptic ulcer). If accidental deaths are excluded, 50% of the deaths in patients with MEN-1 were the result of MEN-1, and the mean age of death (50.9 years)was significantly younger than that of other family members. CONCLUSIONS: It is concluded that MEN-1 leads to premature death, and that neoplasia rather than peptic ulcer disease is the main cause of death. Deaths from pituitary tumor or malignant endocrine tumors within the thorax were just as common or more common than deaths from pancreatic malignant neoplasms.
S Wilkinson; B T Teh; K R Davey; J P McArdle; M Young; J J Shepherd
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  128     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-01     Completed Date:  1993-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  683-90     Citation Subset:  AIM; IM    
Department of Surgery, University of Tasmania, Hobart, Australia.
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MeSH Terms
Cause of Death
Middle Aged
Multiple Endocrine Neoplasia / genetics,  mortality*
Retrospective Studies
Risk Factors
Tasmania / epidemiology

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