Document Detail

Causality in acute encephalitis: defining aetiologies.
MedLine Citation:
PMID:  20388231     Owner:  NLM     Status:  MEDLINE    
Defining the causal relationship between a microbe and encephalitis is complex. Over 100 different infectious agents may cause encephalitis, often as one of the rarer manifestations of infection. The gold-standard techniques to detect causative infectious agents in encephalitis in life depend on the study of brain biopsy material; however, in most cases this is not possible. We present the UK perspective on aetiological case definitions for acute encephalitis and extend them to include immune-mediated causes. Expert opinion was primarily used and was supplemented by literature-based methods. Wide usage of these definitions will facilitate comparison between studies and result in a better understanding of the causes of this devastating condition. They provide a framework for regular review and updating as the knowledge base increases both clinically and through improvements in diagnostic methods. The importance of new and emerging pathogens as causes of encephalitis can be assessed against the principles laid out here.
J Granerod; R Cunningham; M Zuckerman; K Mutton; N W S Davies; A L Walsh; K N Ward; D A Hilton; H E Ambrose; J P Clewley; D Morgan; M P Lunn; T Solomon; D W G Brown; N S Crowcroft
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-14
Journal Detail:
Title:  Epidemiology and infection     Volume:  138     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  783-800     Citation Subset:  IM    
Health Protection Agency Centre for Infections, London NW9 5EQ, UK.
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MeSH Terms
Acute Disease
Amebiasis / complications,  diagnosis
Bacterial Infections / complications,  diagnosis
Encephalitis / diagnosis,  etiology*,  microbiology
Great Britain / epidemiology
Rickettsia Infections / complications,  diagnosis
Toxoplasmosis / complications,  diagnosis
Virus Diseases / complications,  diagnosis

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