Document Detail


Causal hypothesis for some congenital anomalies.
MedLine Citation:
PMID:  16354495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital anomalies are a major cause of fetal and neonatal death and of childhood morbidity. Chromosomal and other genetic abnormalities, environmental teratogens and some nutritional deficiencies account for some congenital anomalies but the majority are of unknown etiology. The hypothesis is here proposed that a significant proportion of congenital anomalies and cerebral palsy of unknown etiology are attributable to a monozygotic multiple conception with monochorionic placentation and that these anomalies, even in singletons, may be explained by early, unrecognized or unrecorded loss of one conceptus in a monochorionic monozygotic conception. The pathological mechanism is hemodynamic instability with episodes of acute feto-fetal transfusion that produce ischemic organ impairment in either or both twins. The resultant clinical abnormality will depend on range of severity (fetal death, infant death, congenital anomaly, normal infant), site or combination of sites (which organ[s] present[s] with the congenital anomaly) and timing (early, middle or late in gestation as shown by variation in brain pathology that is observed).
Authors:
Peter O D Pharoah
Related Documents :
7209535 - Aerial spraying of 2,4,5-t and human birth malformations: an epidemiological investigat...
21333345 - Preterm birth reduces the incidence of atopy in adulthood.
7195325 - Congenital heart diseases at autopsy of still-born and deceased children in the central...
7205325 - Morphogenesis of experimental anencephaly.
15613575 - Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?
24526005 - Quality indicators for human milk use in very low-birthweight infants: are we measuring...
Publication Detail:
Type:  Journal Article; Review; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  8     ISSN:  1832-4274     ISO Abbreviation:  -     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-15     Completed Date:  2006-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  543-50     Citation Subset:  IM    
Affiliation:
FSID Unit of Perinatal and Paediatric Epidemiology, Department of Public Health, University of Liverpool, Liverpool, United Kingdom. p.o.d.pharoah@liv.ac.uk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / etiology*,  pathology
Female
Fetal Death / etiology*,  pathology
Humans
Ischemia / etiology,  pathology
Male
Malnutrition / complications
Maternal Exposure / adverse effects
Pregnancy
Teratogens / toxicity
Chemical
Reg. No./Substance:
0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Peritonitis in patients over the age of 50 years: 98 cases managed surgically.
Next Document:  Problems with using sum scores for estimating variance components: contamination and measurement non...