Document Detail

Causal association between major histocompatibility complex and myocardial infarction in NZW x BXSB F1 mice.
MedLine Citation:
PMID:  7596028     Owner:  NLM     Status:  MEDLINE    
The NZW x BXSB F1 male mice that a model for systemic lupus erythematosus (SLE) develop myocardial infarction. To determine whether the gene(s) linked to the major histocompatibility complex (MHC) of NZW mice are involved in myocardial infarction, we developed an H-2-congenic NZW.H-2d strain and compared the incidence of myocardial infarction in NZW x BXSB F1 (H-2z/b) male mice to that in NZW. H-2d x BXSB F1 male mice (H-2d/b). H-2z/b heterozygous F1 male mice showed a higher incidence of myocardial infarction than H-2d/b F1 male mice. This observation suggests that the myocardial infarction seen in SLE may be related to MHC.
H Kawano; Y Kawano; T Shirai; R Okada
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  59     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-08-01     Completed Date:  1995-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
Research Laboratory for Cardiovascular Pathology, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Antibodies, Anticardiolipin / blood
Crosses, Genetic
Lupus Erythematosus, Systemic / genetics
Major Histocompatibility Complex*
Mice, Inbred Strains
Myocardial Infarction / genetics*,  immunology
Reg. No./Substance:
0/Antibodies, Anticardiolipin

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