| Causal link between neonatal hydronephrosis and later development of hypertension. | |
| | |
MedLine Citation:
|
PMID: 19671072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Although congenital ureteral obstruction is a common disorder in infants, its pathophysiology remains poorly understood and its clinical management continues to be debated. During the past decade, the surgical management of non-symptomatic hydronephrosis in children has become more conservative, but the long-term physiological consequences of this new policy are unclear. 2. In experimental models with complete ureteral obstruction, tubular atrophy and interstitial inflammation occur rapidly. Although this type of obstruction is very rare in clinical practice, it is often referred to in clinical discussions. New studies, using a model with chronic partial ureteral obstruction, have demonstrated that hydronephrosis is associated with renal injuries and is causally related to hypertension. 3. The mechanisms underlying the development of hypertension in experimental hydronephrosis are complex and involve changes in both the renin-angiotensin system and renal sympathetic nerve activity. Furthermore, oxidative stress and nitric oxide deficiency in the diseased kidney, with consequent resetting of the tubuloglomerular feedback mechanism, appear to play a pivotal role in the development and maintenance of hyper-tension. 4. In view of the new knowledge regarding the long-term effects of partial ureteral obstruction, today's non-operative management of hydronephrosis should be reconsidered to prevent obstructive nephropathy and hypertension in later life. |
| | |
Authors:
|
Mattias Carlstr?m |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-08-04 |
Journal Detail:
|
Title: Clinical and experimental pharmacology & physiology Volume: 37 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-24 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
|
Languages: eng Pagination: e14-23 Citation Subset: IM |
Affiliation:
|
Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden. Mattias.Carlstrom@mcb.uu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Child Humans Hydronephrosis / complications*, physiopathology, surgery Hypertension / etiology* Infant Infant, Newborn Kidney / blood supply, injuries, innervation Male Mice Nephritis / pathology Nitric Oxide / deficiency Oxidative Stress / physiology Rats Renin-Angiotensin System / physiology Sympathetic Nervous System / physiopathology Time Ureteral Obstruction / complications*, surgery |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New Strategies for Cancer Gene Therapy: Progresses and Opportunities.
Next Document: CULTURE AND GENETIC SCREENING IN AFRICA.