| Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment. | |
MedLine Citation:
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PMID: 22666262 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones are free from unwanted side effects of their synthetics analogs. Low level of maternal blood ACTH and insufficient increase of induced by hypothalamic hormones oxytocinases (cystine-β-aminopeptidases) were indication to ACTH-depot therapy (0.5 mg/week) in our consecutive prospective studies. Contrary to antenatal use of synthetic corticosteroids, there are no temporal limits of this therapy, which has to be more often recommended into clinical prevention of fetal morbidity, treatment of premature delivery, and finally elimination of the newborn's mortality caused by the neuroendocrinological gestoses. |
Authors:
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Rudolf Klimek; Marek Klimek; Peter Gralek; Dariusz Jasiczek |
Publication Detail:
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Type: Journal Article Date: 2012-05-15 |
Journal Detail:
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Title: Obstetrics and gynecology international Volume: 2012 ISSN: 1687-9597 ISO Abbreviation: Obstet Gynecol Int Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-05 Completed Date: 2012-08-23 Revised Date: 2013-02-28 |
Medline Journal Info:
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Nlm Unique ID: 101517078 Medline TA: Obstet Gynecol Int Country: United States |
Other Details:
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Languages: eng Pagination: 248926 Citation Subset: - |
Affiliation:
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Fertility Centre Cracow, Plac Szczepański 3, 31-011 Cracow, Poland. |
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