Document Detail


Caught red-handed: uric acid is an agent of inflammation.
MedLine Citation:
PMID:  20501951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation occurs in response to both pathogenic insult and tissue damage under sterile conditions, with the latter contributing to the pathogenesis of many diseases. Although several endogenous substances, including uric acid, have been suggested to alert the body to danger and to stimulate inflammation, little is known about their contribution to such responses in vivo. In this issue of the JCI, Kono et al. use newly generated mice with reduced levels of uric acid to investigate its role as an endogenous signal of tissue damage in inflammatory responses to hepatic injury. They find that uric acid is released from dying tissues and induces inflammation to cell death but is not involved in the response to microbial molecules or sterile irritant particles. I believe this to be the first report of an endogenous danger signal acting as a physiological regulator of inflammation.
Authors:
Yan Shi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-24
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-06-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1809-11     Citation Subset:  AIM; IM    
Affiliation:
Immunology Research Group and Department of Microbiology & Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. yshi@ucalgary.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / immunology,  pharmacology
Cell Death / drug effects,  immunology
Inflammation / immunology,  metabolism*
Liver / immunology,  metabolism
Mice
Signal Transduction / drug effects,  immunology*
Uric Acid / immunology,  metabolism*,  pharmacology
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 69-93-2/Uric Acid
Comments/Corrections

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