Document Detail


Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein.
MedLine Citation:
PMID:  23128674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.
Authors:
Martin R Jakobsen; Trine H Mogensen; Søren R Paludan
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Publication Detail:
Type:  Journal Article     Date:  2012-11-06
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  320-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Regulation, Viral / genetics,  physiology
HIV Infections / genetics,  metabolism*
HIV-1 / genetics,  metabolism*
Humans
Interferon Regulatory Factors / genetics,  metabolism*
Virus Replication / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Interferon Regulatory Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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