| Caudate neuronal response to microiontophoretically injected morphine in naive and morphine-dependent rats. | |
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MedLine Citation:
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PMID: 6128174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The response of caudate nucleus neurons to morphine was found to be dose-dependent and could be divided into two classes: neurons which responded monophasically either by increase or decrease in their firing rate, and neurons whose response can be described as biphasic, exhibiting increase followed by decrease in their firing rate or vice versa, with the increase in morphine concentration. These responses were found in both naive and morphine-dependent rats. 2. Naloxone antagonized the effects of morphine in 74 out of 102 neurons tested. 3. Caudate neurons of morphine-dependent rats showed super-sensitivity to morphine compared to naive rats. 4. Differences were found in the distribution of the spontaneously active neurons between naive and morphine-dependent rats, indicating the existence of two different opiate receptor populations within the caudate nucleus. |
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Authors:
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A Schurr; B M Rigor; B T Ho; N Dafny |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. C: Comparative pharmacology Volume: 73 ISSN: 0306-4492 ISO Abbreviation: Comp. Biochem. Physiol. C, Comp. Pharmacol. Publication Date: 1982 |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503763 Medline TA: Comp Biochem Physiol C Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 205-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caudate Nucleus / drug effects* Humans Iontophoresis Male Morphine / pharmacology* Morphine Dependence / physiopathology* Naloxone / pharmacology Neurons / drug effects* Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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