Document Detail


Caudate neuronal response to microiontophoretically injected morphine in naive and morphine-dependent rats.
MedLine Citation:
PMID:  6128174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The response of caudate nucleus neurons to morphine was found to be dose-dependent and could be divided into two classes: neurons which responded monophasically either by increase or decrease in their firing rate, and neurons whose response can be described as biphasic, exhibiting increase followed by decrease in their firing rate or vice versa, with the increase in morphine concentration. These responses were found in both naive and morphine-dependent rats. 2. Naloxone antagonized the effects of morphine in 74 out of 102 neurons tested. 3. Caudate neurons of morphine-dependent rats showed super-sensitivity to morphine compared to naive rats. 4. Differences were found in the distribution of the spontaneously active neurons between naive and morphine-dependent rats, indicating the existence of two different opiate receptor populations within the caudate nucleus.
Authors:
A Schurr; B M Rigor; B T Ho; N Dafny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative biochemistry and physiology. C: Comparative pharmacology     Volume:  73     ISSN:  0306-4492     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503763     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Caudate Nucleus / drug effects*
Humans
Iontophoresis
Male
Morphine / pharmacology*
Morphine Dependence / physiopathology*
Naloxone / pharmacology
Neurons / drug effects*
Rats
Rats, Inbred Strains
Time Factors
Chemical
Reg. No./Substance:
465-65-6/Naloxone; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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