Document Detail


Caudate asymmetry: a neurobiological marker of moderate prenatal alcohol exposure in young adults.
MedLine Citation:
PMID:  20609385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study identified structural changes in the caudate nucleus in offspring of mothers who drank moderate levels of alcohol during pregnancy. In addition, the effect of duration of alcohol use during pregnancy was assessed. Young adults were recruited from the Maternal Health Practices and Child Development Project. Three groups were evaluated: prenatal alcohol exposure (PAE) during all three trimesters (3T), PAE during the first trimester only (1T), and controls with no PAE (0T). Magnetic resonance images were processed using the automated labeling pathway technique. Volume was measured as the number (gray+white) and relative percentage (caudate count/whole brain count x 100) of voxels. Asymmetry was calculated by subtracting the caudate volume on the left from the right and dividing by the total (L-R/L+R). Data analyses controlled for gender, handedness, and prenatal tobacco and marijuana exposures. There were no significant differences between the groups for whole brain, left, or right volumes. There was a dose-response effect across the three exposure groups both in terms of magnitude and direction of asymmetry. In the 3T group, the left caudate was larger relative to the right caudate compared to the 0T group. The average magnitude of caudate asymmetry for the 1T group was intermediate between the 0T and 3T groups. Subtle anatomical changes in the caudate are detected at the moderate end of the spectrum of prenatal alcohol exposure.
Authors:
Jennifer Willford; Richard Day; Howard Aizenstein; Nancy Day
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-06
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  32     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-05-27     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. willford@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alcohol Drinking / adverse effects*
Analysis of Variance
Brain Mapping
Caudate Nucleus / embryology,  growth & development,  pathology*
Female
Functional Laterality / physiology
Humans
Linear Models
Magnetic Resonance Imaging
Male
Marijuana Smoking / adverse effects
Pregnancy
Pregnancy Trimesters
Prenatal Exposure Delayed Effects / chemically induced,  pathology*
Smoking / adverse effects
Young Adult
Grant Support
ID/Acronym/Agency:
AA013981/AA/NIAAA NIH HHS; AA06666/AA/NIAAA NIH HHS; DA003874/DA/NIDA NIH HHS; R01 AA006666-16/AA/NIAAA NIH HHS; R01 AA018116-01/AA/NIAAA NIH HHS
Comments/Corrections

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