| Caudate asymmetry: a neurobiological marker of moderate prenatal alcohol exposure in young adults. | |
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MedLine Citation:
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PMID: 20609385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study identified structural changes in the caudate nucleus in offspring of mothers who drank moderate levels of alcohol during pregnancy. In addition, the effect of duration of alcohol use during pregnancy was assessed. Young adults were recruited from the Maternal Health Practices and Child Development Project. Three groups were evaluated: prenatal alcohol exposure (PAE) during all three trimesters (3T), PAE during the first trimester only (1T), and controls with no PAE (0T). Magnetic resonance images were processed using the automated labeling pathway technique. Volume was measured as the number (gray+white) and relative percentage (caudate count/whole brain count x 100) of voxels. Asymmetry was calculated by subtracting the caudate volume on the left from the right and dividing by the total (L-R/L+R). Data analyses controlled for gender, handedness, and prenatal tobacco and marijuana exposures. There were no significant differences between the groups for whole brain, left, or right volumes. There was a dose-response effect across the three exposure groups both in terms of magnitude and direction of asymmetry. In the 3T group, the left caudate was larger relative to the right caudate compared to the 0T group. The average magnitude of caudate asymmetry for the 1T group was intermediate between the 0T and 3T groups. Subtle anatomical changes in the caudate are detected at the moderate end of the spectrum of prenatal alcohol exposure. |
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Authors:
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Jennifer Willford; Richard Day; Howard Aizenstein; Nancy Day |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-06 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 32 ISSN: 1872-9738 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-05-27 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 589-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. willford@pitt.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alcohol Drinking / adverse effects* Analysis of Variance Brain Mapping Caudate Nucleus / embryology, growth & development, pathology* Female Functional Laterality / physiology Humans Linear Models Magnetic Resonance Imaging Male Marijuana Smoking / adverse effects Pregnancy Pregnancy Trimesters Prenatal Exposure Delayed Effects / chemically induced, pathology* Smoking / adverse effects Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AA013981/AA/NIAAA NIH HHS; AA06666/AA/NIAAA NIH HHS; DA003874/DA/NIDA NIH HHS; R01 AA006666-16/AA/NIAAA NIH HHS; R01 AA018116-01/AA/NIAAA NIH HHS |
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