Document Detail

Caudal hindbrain participation in the suppression of feeding by central and peripheral bombesin.
MedLine Citation:
PMID:  8322979     Owner:  NLM     Status:  MEDLINE    
We have previously demonstrated that bombesin (BBS) infused into the fourth cerebral ventricle in rats suppressed feeding at doses 10-1,000 times less than those required after lateral ventricular administration. These results suggest that centrally administered BBS acts in the caudal hindbrain to suppress food intake. To investigate the participation of caudal hindbrain structures in fourth-ventricular BBS-induced suppression of feeding, we made lesions that destroyed the following: 1) area postrema (AP) and 2) and medial nucleus of the solitary tract (NST). Additionally, we examined the role of the AP/NST in the suppression of food intake after peripheral BBS administration. Our experiments revealed that lesions of the AP/NST abolished the suppression of food intake by fourth-ventricular BBS and attenuated the suppression of food intake by peripheral BBS. Lesions restricted to the AP attenuated the suppression of food intake by fourth-ventricular BBS but had no effect on suppression of intake by peripherally administered BBS. These results suggest that the NST may be a common neural substrate for the inhibition of food intake by both centrally and peripherally administered BBS.
E E Ladenheim; R C Ritter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  264     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1229-34     Citation Subset:  IM    
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164.
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MeSH Terms
Bombesin / administration & dosage,  pharmacology*
Cerebral Ventricles / drug effects,  physiology
Cholecystokinin / administration & dosage,  pharmacology
Dose-Response Relationship, Drug
Eating / drug effects*,  physiology*
Injections, Intraventricular
Medulla Oblongata / drug effects,  physiology
Rats, Sprague-Dawley
Rhombencephalon / drug effects*,  physiology*
Tissue Distribution
Grant Support
Reg. No./Substance:
31362-50-2/Bombesin; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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