| Cauda equina involvement in acute myeloid leukemia relapse. | |
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MedLine Citation:
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PMID: 22145515 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Although central nervous system (CNS) involvement in acute myeloid leukemia has been described in about 2 to 4%, it still represents a major therapeutic problem, particularly cauda eqina involvement that is clinically significant and unusual. Here, a 22-year-old man, with underlying AML (M2-Subtype, FAB classification) and cytogenetic analysis resulted in 45, x, -y, t(8;21) (q22;q22)[15] whose presenting symptoms of low back pain and incontinence, 10 months after first remission, was reported. This was followed by peripheral and bone marrow relapse. The magnetic resonance image (MRI) findings revealed leukemic infiltration at S1-S5 of the spinal cord canal with associated soft tissue component at presacral area encasing bilateral S1-S5 exiting root with heterogeneous enhancement in bone marrow of S2-S4. The therapeutic and prognosis implications of spinal cord involvement by leukemia were discussed. Because of severe morbidity, the patient developed bone marrow failure and died from sepsis. |
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Authors:
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Jitsuda Buakhao; Amarate Tansawet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 94 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-12-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 1271-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Nopparatrajathanee Hospital, Department of Medical Services, MOPH, Thailand. jeab7033@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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