Document Detail

Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.
MedLine Citation:
PMID:  22293415     Owner:  NLM     Status:  MEDLINE    
Three types of animal bile preparation, bear bile (BB), cattle bile (CB) and pig bile (PB) differ in bile acid composition and are supposed to exert different pharmacotoxicological actions. Dietary supplementation with CB at 1% (w/w) for 4 weeks decreased triacylglycerol (TAG) level but increased total cholesterol (CHO) level in serum, which were associated with fatty liver injury in mice. The increased levels of cholesterol esters (CE) and monounsaturated fatty acids (MUFA) in the serum and liver were observed in the mice fed the CB-supplemented diet. Lipid abnormalities and fatty liver injury observed in the mice fed the CB diet were not induced by the supplementation with BB and PB. The supplementation with cholic acid (CA), the most abundant bile acid in CB, could induce lipid abnormalities and fatty liver injury, which were indistinguishable from those induced by CB supplementation. CB and CA supplementation induced similar changes in the expression levels of mRNAs in the liver. Thus, CB induced lipid abnormalities and fatty liver injury, which can be attributed to the actions of CA contained in CB. The inabilities of BB and PB to induce lipid abnormalities and fatty liver injury are supposed to be due to their limited contents of CA.
Shiro Watanabe; Koichi Tsuneyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  37     ISSN:  1880-3989     ISO Abbreviation:  J Toxicol Sci     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-01     Completed Date:  2012-05-17     Revised Date:  2012-05-24    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  105-21     Citation Subset:  IM    
Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Bile* / chemistry
Bile Acids and Salts / analysis
Cholic Acid / analysis,  pharmacology
Fatty Liver / chemically induced*,  metabolism,  pathology
Glyceraldehyde-3-Phosphate Dehydrogenases / genetics
Lipids / blood*
Mice, Inbred ICR
Oligonucleotide Array Sequence Analysis
RNA, Messenger / metabolism
Stearoyl-CoA Desaturase / genetics
Reg. No./Substance:
0/Bile Acids and Salts; 0/Lipids; 0/RNA, Messenger; 81-25-4/Cholic Acid; EC protein, mouse; EC Desaturase; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC Aminotransferases; EC Transaminase

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