Document Detail


Cationic nucleoside lipids based on a 3-nitropyrrole universal base for siRNA delivery.
MedLine Citation:
PMID:  19159294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cationic nucleoside lipids based on a 3-nitropyrrole universal base were prepared from D-ribose using a straightforward chemical synthesis. Several studies including DLS, TEM, and ethidium bromide (EthBr) assay demonstrated that these amphiphilic molecules form supramolecular organizations of nanometer size in aqueous solutions and are able to bind nucleic acids. siRNA knockdown experiments were performed with these nucleolipids, and we observed protein knockdown activity similar to the siPORT NeoFX positive control. No significant cytotoxicity was found.
Authors:
Claire Ceballos; Carla A H Prata; Suzanne Giorgio; Frédéric Garzino; Dominique Payet; Philippe Barthélémy; Mark W Grinstaff; Michel Camplo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  20     ISSN:  1520-4812     ISO Abbreviation:  Bioconjug. Chem.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-04-03     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Gene Knockdown Techniques
Humans
Lipids / chemistry*
Pyrroles / chemistry*,  metabolism*,  toxicity
RNA, Small Interfering / metabolism*
Ribonucleosides / chemistry*,  metabolism*,  toxicity
Transfection / methods*
Grant Support
ID/Acronym/Agency:
R01 EB005658/EB/NIBIB NIH HHS; R01 EB005658-02/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/1-ribofuranosyl-3-nitropyrrole; 0/Lipids; 0/Pyrroles; 0/RNA, Small Interfering; 0/Ribonucleosides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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