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Cationic nucleolipids as efficient siRNA carriers.
MedLine Citation:
PMID:  21082158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We synthesized five novel uridine-based cationic nucleolipids, introducing basic amino acid residues at the 5' position of uridine, through 1,3-dipolar cycloaddition, and hydrophobic alkyl moieties at the 2' and 3' positions, through carbamate linkages. Their lipoplexes delivered siRNAs efficiently to cells, in vitro, without any severe toxicity.
Authors:
Hye Won Yang; Jeong Wu Yi; Eun-Kyoung Bang; Eun Mi Jeon; Byeang Hyean Kim
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Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  9     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Affiliation:
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang, 790-784 Korea. bhkim@postech.ac.kr.
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