| Cationic nucleolipids as efficient siRNA carriers. | |
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MedLine Citation:
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PMID: 21082158 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We synthesized five novel uridine-based cationic nucleolipids, introducing basic amino acid residues at the 5' position of uridine, through 1,3-dipolar cycloaddition, and hydrophobic alkyl moieties at the 2' and 3' positions, through carbamate linkages. Their lipoplexes delivered siRNAs efficiently to cells, in vitro, without any severe toxicity. |
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Authors:
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Hye Won Yang; Jeong Wu Yi; Eun-Kyoung Bang; Eun Mi Jeon; Byeang Hyean Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-11-17 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 9 ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 291-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang, 790-784 Korea. bhkim@postech.ac.kr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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