Document Detail

Cationic nucleolipids as efficient siRNA carriers.
MedLine Citation:
PMID:  21082158     Owner:  NLM     Status:  In-Data-Review    
We synthesized five novel uridine-based cationic nucleolipids, introducing basic amino acid residues at the 5' position of uridine, through 1,3-dipolar cycloaddition, and hydrophobic alkyl moieties at the 2' and 3' positions, through carbamate linkages. Their lipoplexes delivered siRNAs efficiently to cells, in vitro, without any severe toxicity.
Hye Won Yang; Jeong Wu Yi; Eun-Kyoung Bang; Eun Mi Jeon; Byeang Hyean Kim
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Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  9     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang, 790-784 Korea.
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